They can help you to understand that acetaminophen, the active ingredient in TYLENOL®, can be an appropriate pain relief option for patients on aspirin heart therapy because it does not inhibit the heart-healthy benefits of your aspirin therapy and does not irritate the stomach the way that naproxen sodium or even ibuprofen can. For people on aspirin heart therapy, TYLENOL® is the brand of. Fight painful cold and flu symptoms with TYLENOL® Cold and Flu Severe Day/Night. Caplets help clear congestion, quiet cough, and relieve aches and pain.